Cyclin A2:At the crossroads of cell cycle and cell invasion

• 作者: Abdelhalim Loukil Bénédicte Lemmers Caroline T Cheung Jean Marie Blanchard Marion Peter Nawal Bendris
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 生物学
• 关键词: CYCLIN MITOSIS MESENCHYMAL TRANSITION METASTASIS A
• 年，卷（期）: 2015,（4）
• 页码范围: 346-350
• 页数: 5页
• 分类号: Q25

摘要

Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However,whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed,recent observations show that a small fraction of cyclin A2 persists beyond metaphase and is degraded by autophagy. Its implication in the control of cytoskeletal dynamics and cell movement has unveiled its role in the modulation of Rho A activity. Since this GTPase is involved in both cell rounding early in mitosis and later,in the formation of the cleavage furrow,this suggests that cyclin A2 is a novel actor in cytokinesis. Taken together,these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis.