Klotho in cardiovascular disease:Current and future perspectives

• 作者: Carmen Mora-Fernández Ernesto Martín-Nú?ez Javier Donate-Correa Juan F Navarro-González Mercedes Muros-de-Fuentes Nayra Pérez-Delgado
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: KLOTHO CARDIOVASCULAR DISEASE CHRONIC KIDNEY disea
• 年，卷（期）: 2015,（4）
• 页码范围: 351-357
• 页数: 7页
• 分类号: R54

摘要

Protein Klotho,beyond its role as a regulator of the phosphatemia,is also involved in the maintaining of the cardiovascular health,being associated its alterations with the development of cardiovascular damage and increased morbi-mortality. For all this,nowadays Klotho is the subject of a thorough research which is focused on uncover its intimate mechanisms of action,and in analyzing the utility of its modulation as a potential strategy with clinical applicability. Molecular mechanisms of Klotho are not well understood but an emerging research area links Klotho deficiency with vascular pathology. Changes in this protein have been associated with cardiovascular-related complications like inflammation,vascular calcification,and endothelial dysfunction. All this is particularly relevant if considering the recent discovery of Klotho expression in vascular tissue.