Could cancer and infection be adverse effects ofmesenchymal stromal cell therapy？

• 作者: Martha L Arango-Rodriguez Fernando Ezquer Marcelo Ezquer Paulette Conget
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: CANCER INFECTION MESENCHYMAL stem cells THERAPY BIOSAFETY
• 年，卷（期）: 2015,（2）
• 页码范围: 408-417
• 页数: 10页
• 分类号: R

摘要

Multipotent mesenchymal stromal cells [also referred toas mesenchymal stem cells （MSCs）] are a heterogeneoussubset of stromal cells. They can be isolated from bonemarrow and many other types of tissue. MSCs arecurrently being tested for therapeutic purposes （i.e.,improving hematopoietic stem cell engraftment, managinginflammatory diseases and regenerating damagedorgans）. Their tropism for tumors and inflamed sites andtheir context-dependent potential for producing trophicand immunomodulatory factors raises the question asto whether MSCs promote cancer and/or infection. Thisarticle reviews the effect of MSCs on tumor establishment,growth and metastasis and also susceptibility to infectionand its progression. Data published to date shows aparadoxical effect regarding MSCs, which seems todepend on isolation and expansion, cells source anddose and the route and timing of administration. Cancerand infection may thus be adverse or therapeutic effectsarising form MSC administration.