Oral eplerenone for the management of chronic central serous chorioretinopathy

• 作者: Andrew P Schachat Jonathan E Sears Justis P Ehlers Peter K Kaiser Rishi P Singh Rumneek Bedi
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: CENTRAL SEROUS CHORIORETINOPATHY CENTRAL SEROUS RETINOPATHY EPLERENONE subretinal fluid
• 年，卷（期）: 2015,（2）
• 页码范围: 310-314
• 页数: 5页
• 分类号: R774.1

摘要

AIM: To examine eplerenone(Inspra, Pfizer), a mineralocorticoid receptor antagonist, as a treatment option for chronic central serous chorioretinopathy(CSCR).METHODS: A retrospective consecutive case series was conducted for patients receiving oral eplerenone for chronic CSCR. At baseline and each follow-up visit,spectral domain optical coherence tomography(SD-OCT)imaging was performed, including manual measurements of the height and diameter size of subretinal fluid. The primary outcome measure was the reduction in subretinal fluid following initiation of therapy.RESULTS: A total of 17 eyes of 13 patients treated with25 and 50 mg of oral eplerenone per day were identified.Subretinal fluid(SRF) decreased over time following eplerenone therapy(P = 0.007 and P =0.002, diameter and height respectively). Maximum SRF height decreased from a mean of 131.5 μm at baseline to 15.3 μm at day181+. SRF diameter decreased from an average of 2174.4μm at baseline to 46.9 μm at day 181 +. Log MAR visual acuity improved from 0.42(Snellen equivalent: 20/53) at baseline to 0.29(Snellen equivalent: 20/39) at day 181 +(P = 0.024). Central subfield thickness(CST) decreased from 339.5 μm at baseline to 270.3 μm at day 181+(P = 0.029).CONCLUSION: Eplerenone therapy resulted in significant anatomic and visual improvements in eyes with chronic CSCR.