Bioinformatics analysis of potential essential genes that response to the high intraocular pressure on astrocyte due to glaucoma

• 作者: Dian-Wen Gao Dong-Mei Gui Jing-Zhu Duan Yang Yang Yu Di
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: high INTRAOCULAR PRESSURE MICROARRAY GLAUCOMA ASTROCYTES
• 年，卷（期）: 2015,（2）
• 页码范围: 395-398
• 页数: 4页
• 分类号: R775

摘要

AIM: To study the gene expression response and predict the network in cell due to pressure effects on optic nerve injury of glaucoma.METHODS: We used glaucoma related microarray data in public database [Gene Expression Omnibus(GEO)] to explore the potential gene expression changes as well as correspondent biological process alterations due to increased pressure in astrocytes during glaucoma development.RESULTS: A total of six genes were identified to be related with pressure increasing. Through the annotation and network analysis, we found these genes might be involved in cell morphological remodeling, angiogenesis,mismatch repair.CONCLUSION: Increasing pressure in glaucoma on astrocytes might cause gene expression alterations,which might induce some cellular responses changes.