Histone deacetylases and cardiovascular cell lineagecommitment

• 作者: Yang, Jun-Yao Wang, Qian Wang, Wen Zeng, Ling-Fang
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: HISTONE DEACETYLASES Stem CELL ENDOTHELIALCELL Smooth muscle CELL CARDIOVASCULAR diseases
• 年，卷（期）: 2015,（5）
• 页码范围: 852-859
• 页数: 8页
• 分类号: R

摘要

Cardiovascular diseases （CVDs）, which include alldiseases of the heart and circulation system, arethe leading cause of deaths on the globally. Duringthe development of CVDs, choric inflammatory, lipidmetabolism disorder and endothelial dysfunction arewidely recognized risk factors. Recently, the newtreatment for CVDs that designed to regenerate thedamaged myocardium and injured vascular endotheliumand improve recovery by the use of stem cells, attractsmore and more public attention. Histone deacetylases（HDACs） are a family of enzymes that remove acetylgroups from lysine residues of histone proteinsallowing the histones to wrap the DNA more tightlyand commonly known as epigenetic regulators ofgene transcription. HDACs play indispensable roles innearly all biological processes, such as transcriptionalregulation, cell cycle progression and developmentalevents, and have originally shown to be involved incancer and neurological diseases. HDACs are alsofound to play crucial roles in cardiovascular diseases bymodulating vascular cell homeostasis （e.g. , proliferation,migration, and apoptosis of both ECs and SMCs）. Thisreview focuses on the roles of different members ofHDACs and HDAC inhibitor on stem cell/ progenitor celldifferentiation toward vascular cell lineages （endothelialcells, smooth muscle cells and Cardiomyocytes） and itspotential therapeutics.