Enhancing endothelial progenitor cell for clinical use

• 作者: Lei Ye and Kian-Keong Poh
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: ENDOTHELIAL PROGENITOR cells Cell therapy ENHANCING function and NUMBER CD34 CLINICAL trials
• 年，卷（期）: 2015,（6）
• 页码范围: 894-898
• 页数: 5页
• 分类号: R

摘要

Circulating endothelial progenitor cells （EPCs） havebeen demonstrated to correlate negatively with vascularendothelial dysfunction and cardiovascular risk factors.However, translation of basic research into the clinicalpractice has been limited by the lack of unambiguousand consistent definitions of EPCs and reduced EPCcell number and function in subjects requiring them forclinical use. This article critically reviews the definitionof EPCs based on commonly used protocols, their valueas a biomarker of cardiovascular risk factor in subjectswith cardiovascular disease, and strategies to enhanceEPCs for treatment of ischemic diseases.