Mesenchymal stem cells in maxillary sinus augmentation： Asystematic review with meta-analysis

• 作者: Francesco G Mangano, Marco Colombo, Giovanni Veronesi, Alberto Caprioglio, and Carlo Mangano
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: MESENCHYMAL stem cells MAXILLARY SINUS SINUS FLOOR augmentation Scaffolds BONE REGENERATION
• 年，卷（期）: 2015,（6）
• 页码范围: 976-991
• 页数: 16页
• 分类号: R

摘要

AIM To investigate the effectiveness of mesenchymalstem cells （MSCs） in maxillary sinus augmentation（MSA）, with various scaffold materials.METHODS： MEDLINE, EMBASE and SCOPUS weresearched using keywords such as sinus graft, MSA,maxillary sinus lift, sinus floor elevation, MSC and cellbased,in different combinations. The searches includedfull text articles written in English, published over a10-year period （2004-2014）. Inclusion criteria wereclinical/radiographic and histologic/ histomorphometricstudies in humans and animals, on the use of MSCs inMSA. Meta-analysis was performed only for experimentalstudies （randomized controlled trials and controlledtrials） involving MSA, with an outcome measurement ofhistologic evaluation with histomorphometric analysisreported. Mean and standard deviation values ofnewly formed bone from each study were used, andweighted mean values were assessed to account for thedifference in the number of subjects among the differentstudies. To compare the results between the test andthe control groups, the differences of regenerated bonein mean and 95% confidence intervals were calculated.RESULTS： Thirty-nine studies （18 animal studies and 21human studies） published over a 10-year period （between2004 and 2014） were considered to be eligible forinclusion in the present literature review. These studiesdemonstrated considerable variation with respect tostudy type, study design, follow-up, and results. Metaanalysiswas performed on 9 studies （7 animal studiesand 2 human studies）. The weighted mean differenceestimate from a random-effect model was 9.5% （95%CI：3.6%-15.4%）, suggesting a positive effect of stem cellson bone regeneration. Heterogeneity was measured bythe I 2 index. The formal test confirmed the presenceof substantial heterogeneity （I 2 = 83%, P 〈 0.0001）.In attempt to explain the substantial heterogeneityobserved, we considered a meta-regression model withpublication year, support type （animal vs humans） and follow-up length （8 or 12 w