Clinical analysis of risk factors contributing to recurrence of pterygium after excision and graft surgery

• 作者: Hong Kyun Kim Im Hee Shin Joon Ho Park Sang Won Ha
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: PTERYGIUM RECURRENCE CONJUNCTIVAL AUTOGRAFT amniotic membrane GRAFT MITOMYCIN C
• 年，卷（期）: 2015,（3）
• 页码范围: 522-527
• 页数: 6页
• 分类号: R779.6

摘要

AIM: To find the risk factors related to the reproliferation of the pterygial tissue after excision and graft surgery.METHODS: Charts of 130 eyes of 130 patients who had pterygial excision from March 2006 to April 2011 were reviewed. Preoperative pterygium morphology, surgical methods, and adjunctive treatments were statistically analyzed for their relationship with recurrence.RESULTS: During the follow-up period, recurrence was observed in 20 eyes(15.4%). None of the preoperative morphologic features were affected the rate of the recurrence. However, an age 【40y [P =0.085, odds ratio(OR) 3.609, 95% confidence interval(CI) 0.838-15.540]and amniotic membrane graft instead of conjunctival autograft(P =0.002, OR 9.093, 95% CI 2.316-35.698) were statistically significant risk factors for recurrence.Multivariate analysis revealed that intraoperative mitomycin C(MMC)(P =0.072, OR 0.298, 95% CI 0.080-1.115)decreased the rate of recurrence. CONCLUSION: Younger age is a risk factor for reproliferation of pterygial tissue after excision and amniotic membrane transplantation(AMT) are less effective in preventing recurrence of pterygium after excision based on the comparison between conjunctival autograft and AMT. Intraoperative MMC application and conjunctival autograft reduce recurrence.