Duodenal adenoma surveillance in patients with familialadenomatous polyposis

• 作者: Adriana Vaz Safatle-Ribeiro Carlos Augusto Real Martinez. Fábio Guilherme Campos Marianny Sulbaran
• 来源期刊: 世界胃肠内镜杂志：英文版（电子版）
• 学科: 医学
• 关键词: FAMILIAL adenomatous POLYPOSIS ADENOMA DUODENUM SURVEILLANCE Endoscopy DIGESTIVE system
• 年，卷（期）: 2015,（10）
• 页码范围: 950-959
• 页数: 10页
• 分类号: R

摘要

Familial adenomatous polyposis （FAP） is a hereditarydisorder caused by Adenomatous Polyposis Genemutations that lead to the development of colorectalpolyps with great malignant risk throughout life. Moreover,numerous extracolonic manifestations incorporatedifferent clinical features to produce varied individualphenotypes. Among them, the occurrence of duodenaladenomatous polyps is considered an almost inevitableevent, and their incidence rates increase as a patient＇sage advances. Although the majority of patients exhibitdifferent grades of duodenal adenomatosis as theyage, only a small proportion （1%-5%） of patients willultimately develop duodenal carcinoma. Within thiscontext, the aim of the present study was to reviewthe data regarding the epidemiology, classification,genetic features, endoscopic features, carcinogenesis,surveillance and management of duodenal polyps inpatients with FAP.