Phomalactone as the Active Constituent against Mosquitoes from <i>Nigrospora spherica</i>

• 作者: Alden S. Estep James J. Becnel Kumudini M. Meepagala
• 来源期刊: 农业科学(英文)
• 学科: 医学
• 关键词: Nigrospora spherica Phomalactone ANOPHELES quadrimaculatus Aedes aegypti PERMETHRIN Resistance Adulticide LARVICIDE
• 年，卷（期）: 2015,（10）
• 页码范围: 1195-1201
• 页数: 7页
• 分类号: R73

摘要

The culture filtrate of a plant pathogenic fungus that infected Zinnia elegans and Hydrangea macrophylla was investigated for mosquitocidal constituents by bioassay guided isolation. The fungus responsible for the pathogenic effects on Zinnia elegans and Hydrangea macrophylla plants had been identified as Nigrospora spherica by molecular techniques. The mosquito adulticidal constituent in the culture filtrate was identified as phomalactone by spectroscopic techniques. Laboratory bioassays showed that phomalactone had larvicidal activity against permethrin susceptible and resistant Aedes aegypti larvae and topical adulticide activities on permethrin susceptible and resistant Aedes aegypti and Anopheles quadrimaculatus mosquitoes. Phomalactone was effective as a topical adulticide against the standard Orlando reference strain of Ae. aegypti with an LD50 of 0.64 μg/org. Activity against An. quadrimaculatus was 0.20 μg/org.