Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation
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摘要:
Dear Editor,
The Hippo-YAP pathway is an evolutionally conserved signaling module that controls tissue growth during development and its dysregulation causes cancer [1].Core components of the Hippo pathway include a kinase cascade comprising MST1/2 and LATS1/2 kinases,in which MST1/2 phosphorylates and activates LATS1/2 [2].