3-79 Live Cell Imaging Study of XRCC1 Kinetics at the

• 作者: Chen Hao Du Guanghua Guo Jinlong Guo Na Liu Wenjing Wei Junzhe Wu Ruqun
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 关键词: LIVE CELL IMAGING
• 年，卷（期）: 2015,（1）
• 页码范围: 186-186
• 页数: 1页
• 分类号: O4

摘要

DNA strand breaks can lead to cell carcinogenesis or cell death if not repaired rapidly and efficiently. An online live cell imaging system was established at the high energy microbeam facility at the Institute of Modern Physics (IMP) to study early and fast cellular response to DNA damage after high linear energy transfer (LET) ion radiation. HT1080 cells expressing XRCC1-RFP were irradiated with single high energy nickel ions, and time-lapse images of the irradiated cells were obtained online.