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This research provides, to the authors’ knowledge, the first integrative model of oxidative stress and C1 metabolism in plants. Increased oxidative stress can cause irreversible damage to photosynthetic components and is harmful to plants. Perturbations at the genetic level may increase oxidative stress and upregulate antioxidant systems in plants. One of the key mechanisms involved in oxidative stress regulation is the ascorbate-glutathione cycle which operates in chloroplasts as well as the mitochondria and is responsible for removal of reactive oxygen species (ROS) generated during photosynthetic operations and respiration. In this research, the complexity of molecular pathway systems of oxidative stress is modeled and then integrated with a previously developed in silico model of C1 metabolism system. This molecular systems integration provides two important results: 1) demonstration of the scalability of the CytoSolve&#174?Collaboratory&#153, a computational systems biology platform that allows for modular integration of molecular pathway models, by coupling the in silico model of oxidative stress with the in silico model of C1 metabolism, and 2) derivation of new insights on the effects of oxidative stress on C1 metabolism relative to formaldehyde (HCHO), a toxic molecule, and glutathione (GSH), an important indicator of oxidative homeostasis in living systems. Previous in silico modeling of C1 metabolism, without oxidative stress, observed complete removal of formaldehyde via formaldehyde detoxification pathway and no change in glutathione concentrations. The results from this research of integrative oxidative stress with C1 metabolism, however, demonstrate significant upregulation of formaldehyde concentrations, with concomitant downregulation and depletion of glutathione. Sensitivity analysis indicates that kGSH-HCHO, the rate constant of GSH-HCHO binding, VSHMT, the rate of formation of sarcosine from glycine, and , the rate of superoxide formation significantly affect formaldehyde homeostasis in the
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篇名 Integrative Modeling of Oxidative Stress and C1 Metabolism Reveals Upregulation of Formaldehyde and Downregulation of Glutathione
来源期刊 美国植物学期刊(英文) 学科 医学
关键词 C1 METABOLISM Oxidative Stress FORMALDEHYDE GLUTATHIONE FORMALDEHYDE Detoxification METHIONINE Biosynthesis Methylation Cycle Computational SYSTEMS Biology CytoSolve SYSTEMS Integration Molecular Pathways
年,卷(期) 2015,(9) 所属期刊栏目
研究方向 页码范围 1527-1542
页数 16页 分类号 R73
字数 语种
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研究主题发展历程
节点文献
C1
METABOLISM
Oxidative
Stress
FORMALDEHYDE
GLUTATHIONE
FORMALDEHYDE
Detoxification
METHIONINE
Biosynthesis
Methylation
Cycle
Computational
SYSTEMS
Biology
CytoSolve
SYSTEMS
Integration
Molecular
Pathways
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
美国植物学期刊(英文)
月刊
2158-2742
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
1814
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0
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