Network of co-mutations in Ebola virus genome predicts the disease lethality

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2015,（6）
• 页码范围: 753-756
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2015.54

摘要

Dear Editor, Zaire ebolavirus (EBOV) is one of the most lethal human viruses with observed high case fatality rate (CFR) of up to 90％.The elucidation of how the genetic changes of EBOV link to its lethality will not only help us to rapidly assess the severity of the current and future EBOV outbreaks but also facilitate a deep understanding of the virus evolution.The EBOV together with the other four strains of ebolaviruses belongs to the Filoviridae RNA virus family [1] and was first identified in 1976 in the Ebola river region of Zaire (now Democratic Republic of Congo) in the Central Africa [2].