Presence of Fleischer ring and prominent corneal nerves in keratoconus relatives and normal controls

• 作者: Andrs Berta Gergely Losonczy Lili Takcs gnes Kriszt
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: forme fruste/subclinical keratoconus Fleischer 戒指 角膜的神经 角膜的变瘦 videokeratographic 索引 因医生之治疗而引的 keratectasia
• 年，卷（期）: 2015,（5）
• 页码范围: 922-927
• 页数: 0页
• 分类号: R772.2

摘要

AIM: To examine the occurrence of commonly known clinical signs of keratoconus(KC), i.e. Fleischer ring,prominent corneal nerves and thinning, among unaffected family members of KC patients and healthy control individuals.·METHODS: Data of both eyes of 117 relatives of KC patients having no manifest disease based on videokeratography indices(KC relatives), and 142 controls were used for Pearson correlation and t-test statistics. Correlation of Fleischer ring, prominent corneal nerves and central pachymetry data were tested with each other and with videokeratography indices(KSI,KISA, 3 and 6 mm Fourier asymmetry, and I-S).·RESULTS: A moderate correlation was found between Fleischer ring and all examined topographical indices.Most important correlation was present with 6 mm Fourier asymmetry, and corneal pachymetry(r =0.272, P <0.001; r=-0.234, P =0.027, respectively). Similar correlations were found with prominent corneal nerves(r =0.234, P <0.001 for 6 mm Fourier asymmetry and r =-0.235, P =0.0265 for pachymetry). KC family members who exhibited Fleischer ring or prominent nerves had thinner and more asymmetric corneas than those without Fleischer ring or prominent corneal nerves(P <0.05 for pachymetry and topographic indices with t-test and Mann-Whitney rank sum test). Though rarely, Fleischer ring and prominent corneal nerves occurred among normal controls, indicating the existence of forme fruste cases in the normal population. Control subjects, who had corneal Fleischer ring or prominent nerves had corneas more similar to KC than other controls(t-test:increased KSI and KISA, P =0.048 and 0.012,respectively).·CONCLUSION: In KC family members and healthy individuals, Fleischer ring and prominent corneal nervesare associated with features of KC and may suggest a possibility of forme fruste KC. Searching for the possible presence of Fleischer ring or prominent nerves on the cornea may help in the decision whether or not to diagnose subclinical KC in a borderline case.