Phytochemical Study and Evaluation of Cytotoxicity, Antioxidant and Hypolipidemic Properties of <i>Launaea taraxacifolia</i>Leaves Extracts on Cell Lines HepG2 and PLB985

• 作者: Dominique Sohounhloué Laurent Combettes Mahudro Yovo Oliver Nusse Omédine Koukoui Pascal Agbangnan Sylviane Boucherie
• 来源期刊: 美国植物学期刊(英文)
• 学科: 医学
• 关键词: Launaea taraxacifolia PHYTOCHEMICAL CYTOTOXICITY ANTIOXIDANT HYPOLIPIDEMIC
• 年，卷（期）: mgzwxqkyw_2015,（11）
• 页码范围: 1768-1779
• 页数: 12页
• 分类号: R73

摘要

Launaea taraxacifolia is a leafy vegetable of the family of Asteraceae (Compositae) found in several countries in West Africa including Ghana, Benin and Nigeria. The plant leaves are eaten either fresh as salad or cooked as sauces. They are also consumed as infusion to fight against several diseases including non-communicable diseases such as diabetes and hypertension. Several studies have been conducted in Ghana, Nigeria on the nutritional and medicinal values of this plant but no study has yet been conducted in Benin on the virtues of this plant. In this work we have achieved the phytochemical characterization and evaluated the cytotoxicity as well as hypolipidemic and anti-oxidant effects of the ethanol-aqueous extracts of Launaea taraxacifolia leaves. Cytotoxicity and hypolipidemic activities have been performed on HepG2 cells;the antioxidant effect has been performed on the PLB985 cells. The results showed that the ethanol-aqueous extracts of Launaea taraxacifolia leaves contained the following metabolites: catechic tannin, flavonoids, phenolic acids, mucilage and leucoanthocyanins. Only very high concentrations (>20 mg/ml) of leaves extracts are toxic for HepG2 cells. Launaea taraxacifolia leaves have significant antioxidant and hypolipidemic activities.