The Aromatic Plant <i>Satureja horvatii</i>ssp. <i>macrophylla</i>Induces Apoptosis and Cell Death to the A549 Cancer Cell Line

• 作者: Anna Batistatou Georgios Manos Marilena E. Lekka Paraskevi Yfanti
• 来源期刊: 美国植物学期刊(英文)
• 学科: 医学
• 关键词: SATUREJA horvatii spp. macrophylla APOPTOSIS Cytotoxicity A549 GC/MS
• 年，卷（期）: mgzwxqkyw_2015,（13）
• 页码范围: 2092-2103
• 页数: 12页
• 分类号: R73

摘要

S. horvatii ssp. macrophylla (Lamiaceae) is an endemic aromatic plant of Greece and is used as a culinary herb. In the present study we explored its possible anticancer activity through the induction of apoptosis on cancer cells using A549 cell line as a model. The cytotoxic effects and the type of cell death (apoptosis/necrosis) were evaluated with biochemical and morphological criteria. The total methanol extract of S. horvatii ssp. macrophylla revealed forty two components, of which carvacrol was the major constituent (43.2%). Only a minor portion of them (3.41%) was contained in the active working plant extract solution which was used for cell treatment. This study indicates that extract of S. horvatii spp. macrophylla, which belongs to carvacrol chemotype, can induce both apoptosis and necrosis to A549 cancer cell line.