A study of retinal parameters measured by optical coherence tomography in patients with multiple sclerosis

• 作者: Sai-Jing Hu Yi Zhang Yi-An You
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: 多重硬化 网膜的神经纤维层厚度 有斑点的体积 视觉地 光连贯断层摄影术
• 年，卷（期）: 2015,（6）
• 页码范围: 1211-1214
• 页数: 0页
• 分类号: R744.51

摘要

AIM: To investigate the difference of retinal nerve fiber layer(RNFL) thickness and macular fovea thickness/volume between multiple sclerosis(MS) patients and healthy normal individuals using optical coherence tomography(OCT) and assess its association with visual field parameters.· METHODS: Thirty consecutive MS patients and 28 healthy controls were recruited in this prospective study.Comprehensive standardized ophthalmic examinations included visual acuity, cycloplegic refraction, intraocular pressure, gonioscopy, visual field, and RNFL thickness and macular fovea thickness/volume detection using Humphrey OCT. Mean values for the thickness of the peripapillary RNFL and macular volume were calculated.Associations between visual field parameters and RNFL thickness/macular volume were analyzed by Pearson correlation analysis.·RESULTS: The RNFL thicknesses in each quadrant,the average macular thickness, and the average macular volume in MS patients were all less than those in healthy controls, with statistically significant differences. The RNFL thickness and macular fovea thickness/volume were greater in eyes without optic neuritis than in eyes with optic neuritis. The average visual field parameters had positive correlations with the RNFL thickness and negative correlations with macular parameters in MS patients.· CONCLUSION: OCT measurements can effectively identify the nerve changes of MS patients, which provide more data for the diagnosis of MS.