Roles of plasmablasts in IgG4-related disease and various immune-based diseases

• 作者: Syuichi Koarada Yoshifumi Tada
• 来源期刊: 世界风湿病学杂志
• 学科: 医学
• 关键词: Plasmablast CD180 IgG4-related DISEASE AUTOIMMUNE DISEASE
• 年，卷（期）: 2016,（1）
• 页码范围: 16-22
• 页数: 7页
• 分类号: R

摘要

IgG4-related disease(IgG4-RD)is a systemic fibroinflammatory disease with multiple organ disorders.Recently,in IgG4-RD,increased circulating plasmablasts have been found.The subsets of plasmablasts are negative for RP105(CD180).A large population of B cells lacking RP105(RP105-negative B cells)are found in patients with active with systemic lupus erythematosus and other systemic autoimmune diseases,including dermatomyositis,and Sj?gren’s syndrome.In other conditions,such as neuromyelitis optica,Kawasaki’s disease,primary biliary cirrhosis and aging,RP105 expression on B cells and monocytes also alters.We review the basic science and clinical significance of RP105-negative B cells including plasmablasts in various immune-based diseases.RP105-negative B cells,especially plasmablasts,play crucial roles in both systemic and organ-specific autoimmune and inflammatory disorders.