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摘要:
For a long time, treatment of peritoneal metastases(PM) was mostly palliative and thus, this status was linkwith "terminal status/despair". The current multimodaltreatment strategy, consisting of cytoreductive surgery(CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC), has been strenuously achieved over time, butseems to be the best treatment option for PM patients.As we reviewed the literature data, we could emphasizesome milestones and also, controversies in the historyof proposed multimodal treatment and thus, outlinethe philosophy of this approach, which seems to be anunusual one indeed. Initially marked by nihilism and fear,but benefiting from a remarkable joint effort of humanand material resources (multi-center and -institutionalresearch), over a period of 30 years, CRS and HIPECfound their place in the treatment of PM. The next 4years were dedicated to the refinement of the multimodaltreatment, by launching research pathways. In selectedpatients, with requires training, it demonstrated asignificant survival results (similar to the HepaticMetastases treatment), with acceptable risks and costs.The main debates regarding CRS and HIPEC treatmentwere based on the oncologists' perspective and the smallnumber of randomized clinical trials. It is important tostatement the PM patient has the right to be informedof the existence of CRS and HIPEC, as a real treatmentresource, the decision being made by multidisciplinaryteams.
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篇名 Multimodality treatment strategies have changed prognosisof peritoneal metastases
来源期刊 世界胃肠肿瘤学杂志:英文版(电子版) 学科 医学
关键词 Hyperthermic INTRAPERITONEAL CHEMOTHERAPY PERITONECTOMY procedures Systemic CHEMOTHERAPY PERITONEAL METASTASES Survival
年,卷(期) 2016,(1) 所属期刊栏目
研究方向 页码范围 67-82
页数 16页 分类号 R
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Hyperthermic
INTRAPERITONEAL
CHEMOTHERAPY
PERITONECTOMY
procedures
Systemic
CHEMOTHERAPY
PERITONEAL
METASTASES
Survival
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世界胃肠肿瘤学杂志:英文版(电子版)
月刊
1948-5204
北京市朝阳区东四环中路62号楼远洋国际中
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664
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0
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