Interactions between traffic air pollution and glutathione S-transferase genes on childhood asthma

• 作者: Ching-Hui Tsai Ming-Wei Su Yungling Leo Lee
• 来源期刊: 世界呼吸病学杂志
• 学科: 医学
• 关键词: Nitrogen dioxide GSTP1 ASTHMA WHEEZE Children
• 年，卷（期）: sjhxbxzz_2016,（1）
• 页码范围: 33-41
• 页数: 9页
• 分类号: R

摘要

AIM:To evaluate the role of glutathione S-transferase P1(GSTP1)genetic polymorphisms potentially modifying the association between NO2 and asthma/wheeze in Taiwanese children.METHODS:We investigated 3714 schoolchildren in Taiwan Children Health Study from 14 communities.Children’s information was measured from questionnaire by parents.The traffic air pollutant was available from Environmental Protection Administration monitoring stations.RESULTS:A two-stage hierarchical model and a multiple logistic regression model were fitted to estimate the effects of NO2 exposures and GSTs polymorphisms on the prevalence of asthma and wheeze.Among children with GSTP1 Ile/Val or Val/Val genotypes,those residing in high-NO2 communities had significantly increased risks of asthma(OR=1.76,95%CI:1.15-2.70),lateonset asthma(OR=2.59,95%CI:1.24-5.41),active asthma(OR=1.93,95%CI:1.05-3.57),asthma under medication(OR=2.95,95%CI:1.37-6.32)and wheeze(OR=1.54,95%CI:1.09-2.18)when compared with children in low-NO2 communities.Significant interactions were noted between ambient NO2 and GSTP1 on asthma,late-onset asthma,asthma under medication and wheeze(P for interaction<0.05).However,we did not find any association with polymorphisms in GSTM1 and GSTT1.CONCLUSION:Children under high traffic air pollution exposure are more susceptible to asthma,especially among those with GSTP1 Val allele.