Advances and perspectives on cellular therapy in acquired bone marrow failure diseases

• 作者: Allshine Chen Jeffrey J Pu Kai-Lin Xu Witold B Rybka Xiao-Shen Sun Xin Liu
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: Bone marrow failure DISEASES APLASTIC anemia Cellular therapy Stem cell transplantation PAROXYSMAL NOCTURNAL HEMOGLOBINURIA MYELODYSPLASTIC syndrome
• 年，卷（期）: 2016,（1）
• 页码范围: 31-36
• 页数: 6页
• 分类号: R

摘要

Acquired bone marrow failure diseases(ABMFD)are a class of hematopoietic stem cell diseases with a commonality of non-inherited disruption of hematopoiesis that results in pancytopenia.ABMFDs also are a group of heterogeneous diseases with different etiologies and treatment options.The three most common ABMFDs are aplastic anemia,myelodysplastic syndrome,and paroxysmal nocturnal hemoglobinuria.Stem cell transplantation is the only treatment that can cure these diseases.However,due to high therapy-related mortality,stem cell transplantation has rarely been used as a first line treatment in treating ABMFD.With the advance of personalized medicine and precision medicine,various novel cellular therapy strategies are in trial to increase the efficiency and efficacy of ABMFD treatment.This article aims to review current available stem cell transplantation protocols and promising cellular therapy research in treating ABMFD.