Comparisons between glucose analogue 2-deoxy-2-(18F)fluoro-D-glucose and 18F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions

• 作者: Ambra Buschiazzo Andrea Bruno Andrea DeCensi Arnoldo Piccardo Claudio Campus Francesca Bongioanni Francesco Fiz Gianmario Sambuceti Irene Bossert Lucia Tixi Mehrdad Naseri Michele Pennone Roberta Gonella Selene Capitanio Silvia Morbelli Vania Altrinetti
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: 18F-sodium positron emission tomography/ computed TOMOGRAPHY Breast cancer Bone lesion 2-deoxy-2-(18F)fluoro-D-glucose
• 年，卷（期）: 2016,（2）
• 页码范围: 200-209
• 页数: 10页
• 分类号: R737.9

摘要

AIM: To compare 2-deoxy-2-(18F)fluoro-D-glucose(18FFDG) and 18F-sodium(18F-NaF) positron emission tomography/computed tomography（PET/CT） accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent 18F-FDG and 18F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity（Se）, specificity（Sp）, overall accuracy, positive and negative predictive values, error rate, and Youden’s index. Mc Nemar’s χ2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT（sclerotic, lytic, mixed, no-lesions） and the divergent site of disease（skull, spine, ribs, extremities, pelvis）. The impact of adding 18F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to 18F-Na F PET/CT findings. RESULTS: The two imaging methods of 18F-FDG and 18F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively（Mc Nemar’s χ2 = 6.23, df = 1, P = 0.01）. Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis（Mc Nemar’s χ2 = 93.4, df = 1, P < 0.0001）. In the lesion density-based and site-based analysis, 18F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis（P < 0.002） and vertebral localizations（P < 0.002）; 18F-Na F PET/CT was more accurate in detecting sclerotic（P < 0.005） and rib lesions（P < 0.04）. 18F-Na F PET/CT led to a change of mana