In the current data-intensive era, the traditional hands-on method ofconducting scientific research by exploring related publications to generate a testablehypothesis is well on its way of becoming obsolete within just a year or two.Analyzing the literature and data to automatically generate a hypothesis mightbecome the de facto approach to inform the core research efforts of those trying tomaster the exponentially rapid expansion of publications and datasets. Here,viewpoints are provided and discussed to help the understanding of challengesof data-driven discovery.