MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer

• 作者: Rui Yi Yao Li Fei-Liang Wang Gang Miao Ruo-Mei Qi Yan-Yang Zhao
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: MicroRNA DIAGNOSIS PROGNOSIS COLORECTAL cancer Biomarkers
• 年，卷（期）: 2016,（4）
• 页码范围: 330-340
• 页数: 11页
• 分类号: R735.34

摘要

MicroRNAs(miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miR NAs in colorectal cancer(CRC) diagnosis. We also shed light on the important corresponding miR NA targets and on the major regulators of miR NAs. Furthermore, we discuss miR NA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miR NAs, the advantages of a therapeutic strategy based on the delivery of miR NA mimics are also mentioned. Together, mi RNA seems to be an excellent tool for effectively monitoring and targeting CRC.