Bilirubin in coronary artery disease:Cytotoxic or protective?

• 作者: Gurprataap Singh Sandhu Nancy Gupta Rahul Chaudhary Rahul Gupta Roxana Bodin Sachin Sule Sushil K Garg Tavankit Singh Varun Mittal
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: BILIRUBIN 细胞毒素 保护 抗氧化剂 反煽动性 反冠的动脉疾病 类脂化合物 peroxidation 吉伯
• 年，卷（期）: 2016,（4）
• 页码范围: 469-476
• 页数: 8页
• 分类号: R575

摘要

Bilirubin has traditionally been considered a cytotoxic waste product.However,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative functions.These properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative stress.In fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD.In this article,we review the current literature exploring the association between levels of bilirubin and risk of CAD.We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established.