Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?

• 作者: Kei Lui Lee Sutton Mark Safe Steven T Leach Usha Krishnan Wei H Chan
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Gastroesophageal 倒流 婴儿 质子泵禁止者 RANITIDINE 安全 不利事件
• 年，卷（期）: 2016,（4）
• 页码范围: 531-539
• 页数: 9页
• 分类号: R725.7

摘要

Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions.