Evaluation of DNA synthesis with carbon-11-labeled 4′-thiothymidine

• 作者: Jun Toyohara
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: 4′-[methyl-11C]-thiothymidine DNA synthesis Cell PROLIFERATION TUMOR POSITRON EMISSION TOMOGRAPHY
• 年，卷（期）: 2016,（9）
• 页码范围: 799-808
• 页数: 10页
• 分类号: R730.44

摘要

In the cancer research field, the preferred method for evaluating the proliferative activity of cancer cells invivo is to measure DNA synthesis rates. The cellular proliferation rate is one of the most important cancer characteristics, and represents the gold standard of pathological diagnosis. Positron emission tomography(PET) has been used to evaluate in vivo DNA synthetic activity through visualization of enhanced nucleoside metabolism. However, methods for the quantitative measurement of DNA synthesis rates have not been fully clarified. Several groups have been engaged in research on 4′-[methyl-~11C]-thiothymidine(~11C-4DST) in an effort to develop a PET tracer that allows quantitative measurement of in vivo DNA synthesis rates. This minireview summarizes the results of recent studies of the in vivo measurement of cancer DNA synthesis rates using ~11C-4DST.