Before applying the Response surface methodology(RSM)methodology,it is first necessary to choose an experimental design that will define which experiments should be carried out in the experimental region being studied.There are some experimental matrices for this purpose.Experimental designs for first-order models can be used when the data set does not present curvature.However,to approximate a response function to experimental data that cannot be described by linear functions,experimental designs for quadratic response surfaces should be used,such as the approach to the applications of its more frequently used second-order experimental designs is broached,as well as the optimization of procedures that generate multiple responses.