4-54 Inhibiting Autophagy Enhances the Anti-tumor Effect of High-LET Carbon Ions via Promoting ER Stress-related Apoptosis

• 作者: Jin Xiaodong Li Qiang Zheng Xiaogang
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 年，卷（期）: 2016,（1）
• 页码范围: 179-179
• 页数: 1页
• 分类号: O4

摘要

Autophagy is an evolutionarily conserved catabolic process directly related to human health and various diseases.Autophagy helps cells under stress to cope with severe metabolic demand by degradation of basic cellular components.Diverse physiological or pathological changes may lead to endoplasmic reticulum(ER)stress.In response to ER stress,BiP disassociates from sensor proteins PERK,ATF6,and IRE1 and then the unfolded protein response(UPR)is activated.The UPR essentially aims at reestablishing proper ER homeostasis and eventually induces autophagy and apoptosis during acute or persistent ER stress.