4-55 Biological Effects of Iron Ion Radiation in Mice

• 作者: Li Hongyan Yan Jiawei Zhang Hong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 年，卷（期）: 2016,（1）
• 页码范围: 179-182
• 页数: 4页
• 分类号: O4

摘要

Cosmic radiation and microgravity are the two main factors of the space environment affecting the health of astronauts[1].The high background level of ionizing radiation is particularly dangerous during missions of long duration[2],since exposure to cosmic radiation causes oxidative damage that induces DNA lesions,cancer,cell death[3]and other adverse effects[4].Protons and ions of high atomic number and energy(HZE)particles are the main source of radiation that astronauts are exposed to[5],and the high ionization density of heavy ions in particular causes complex DNA damage that is more difficult to repair than conventional radiation-induced damage from X-rays and-rays[6].Heavy ion radiation(HIR)kills cells by a combination of direct and indirect actions.Direct actions involve a direct hit on a biologically important target by a particle or beam,and this causes more damage than indirect actions that involve water-derived free radicals[7].