Tumor angiogenesis is the formation of new blood vessels from the existing vascular bed to provide tumor cells with sufficient oxygen,nutrients,etc.,and consequently contributes to tumorigenesis,invasion and metastasis of solid tumor.Hence,Anti-angiogenesis is a desirable strategy for tumor therapy.Chinese herbal medicine(CHM)and their extracts are emerging as the noticeable choice for its multi-level,multi-target and coordinated intervention effects against tumor such as Danshen,Angelica,Chuan xiong,Apigenin,Silibinin,Wogonin[1??2].Curcumin derived from the spice plant Curcuma longa,a powerful anti-cancer agent,has a strong anti-inflammatory and antioxidant functions.The aim of the current study was to explore the combinated application of curcumin and radiation in inhibition of angiogenesis of tumor.