Is the determination of ctDNA a scientific“spy”that foresees cancer?

• 作者: Joana Espiga de Macedo Manuela Machado
• 来源期刊: 世界呼吸病学杂志
• 学科: 医学
• 关键词: TUMOUR BIOPSIES Liquid BIOPSIES CIRCULATING TUMOUR DNA Precision CANCER MEDICINE
• 年，卷（期）: 2017,（2）
• 页码范围: 35-38
• 页数: 4页
• 分类号: R

摘要

Since 1948,circulating tumour DNA(ctDNA)was first identified in human blood.ctDNA is in fact DNA shed by tumour cells from all metastatic tumour locations throughout the whole body,and is thrown into the bloodstream and can then be isolated by a standard blood draw.Using this technique scientists can obtain a wide view of tumour heterogeneity,identify different mechanisms of drug resistance,what is its predominance and the clinical rational of precision cancer medicine become a part of our daily practice.Secondly,early detection of cancer may also contribute to global decrease in cancer mortality.