L-Arginine Levels among Hypertensive Patients in Sokoto, North Western Nigeria

• 作者: A. B. Ibrahim A. H. Chiroma A. Okwesili F. P. Udomah H. Buhari H. M. Liman I. P. Iwueke K. Ibrahin K. Van Dyke M. Ahmed M. Imoru N. B. Egenti O. Erhabor O. Onuigwe Y. Abdulrahaman
• 来源期刊: 血液病期刊(英文)
• 学科: 医学
• 关键词: L-ARGININE HYPERTENSIVE Patients Sokoto NIGERIA
• 年，卷（期）: 2017,（1）
• 页码范围: 1-15
• 页数: 15页
• 分类号: R5

摘要

Hypertension is a major public health problem that adversely affects the health status of individuals, families and communities. L-arginine levels of a total of 90 consecutively-recruited hypertensive subjects and 50 age-matched non-hypertensive controls were studied. Plasma from subjects and control participants were analyzed for L-arginine. The mean values of L-arginine level were significantly lower among the hypertensive subjects which are (174.33 ± 78.31 μmol/L) compared to those of the 50 non-hypertensive controls (237.82 ± 261.16 μmol/L) (p = 0.04). There was no statistically significant difference in the L-arginine levels of hypertensive subjects based on gender, age and ethnici-ty (p = 0.87, 0.23 and 0.57) respectively. The L-arginine level was significantly higher among married hypertensive subjects (181.71 ± 78.17 μmol/L) compared to single or unmarried subjects (130.62 ± 65.99 μmol/L) (p = 0.03). The mean value of L-arginine level was significantly higher among hypertensive subjects with mild blood pressure (187.63 ± 77.93 μmol/L) compared to those with high blood pressure (156.93 ± 76.31 μmol/L). The difference however was not statistically significant (p = 0.05). The findings from this study confirm that the level of L-arginine is lower among hypertensive subjects compared to non-hypertensive controls. Age, gender and ethnicity did not have a significant effect on the L-arginine levels of hypertensive subjects. L-arginine level was significantly lower among single hypertensive patients and those with markedly raised blood pressure. It is recommended the L-arginine supplement be prescribed to hypertensive patient as a prophylactic measure. There is a need to enlighten hypertensive patients in the area on the need to maintain a balanced diet containing sufficient level of L-arginine.