Synthesis, Characterization and <i>In Vitro</i>Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives

• 作者: Ahmed M. El-Morsy Hamada S. Abulkhair Mohamed S. El-Sayed
• 来源期刊: 药物化学期刊(英文)
• 学科: 医学
• 关键词: Pyrazolo[3 4-d]Pyrimidine ANTITUMOR Human BREAST ADENOCARCINOMA Cell Line MCF7
• 年，卷（期）: 2017,（1）
• 页码范围: 1-17
• 页数: 17页
• 分类号: R73

摘要

A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The structures of the new derivatives were confirmed by the spectral data and elemental analyses. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten were revealed mild to moderate activity compared with doxorubicin as a reference antitumor. Among this new series N-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide (13a) was found the most active one with IC50 equal to 23 μM.