基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
Objective: Although deep brain stimulation(DBS) and motor cortex stimulation(MCS)are effective in patients with refractory neuropathic pain, their application is still empirical; there is no consensus on which technique is better. Methods: To enhance the success rate of trial stimulation of invasive neuromodulation techniques and identify approapriate stimulation targets in individual patients, we performed a simultaneous trial of thalamic ventralis caudalis(Vc) DBS and MCS in 11 patients with chronic neuropathic pain and assessed the results of the trial stimulation and long-term analgesia. Results: Of the 11 patients implanted with both DBS and MCS electrodes, nine(81.8%)had successful trials. Seven of these nine patients(77.8%) responded to MCS, and two(18.2%) responded to Vc DBS. With long-term follow-up(56 ± 27.5 months), the mean numerical rating scale decreased significantly(P < 0.05). The degree of percentage pain relief in the chronic MCS(n = 7) and chronic DBS(n = 2) groups were 34.1% ± 18.2%and 37.5%, respectively, and there was no significant difference(P = 0.807). Five out of the seven MCS patients(71%) and both DBS patients had long-term success with the treatments, defined as >30% pain relief compared with baseline. Conclusions: With simultaneous trial of DBS and MCS, we could enhance the success rate of invasive trials. Considering the initial success rate and the less invasive nature of epidural MCS over DBS, we suggest that MCS may be a better, initial means of treatment in chronic intractable neuropathic pain. Further investigations including other subcortical target-associated medial pain pathways are warranted.
推荐文章
The use of in-situ cosmogenic 21Ne in studies on long-term landscape development
Cosmogenic nuclides
21Ne
Long timescale
Landscape evolution
Geochemical tracing and modeling of surface and deep water-rock interactions in elementary granitic
Weathering
Water pathways
U activity ratios
Sr isotope ratios
Anthropogenic gases (CFC,SF6)
CZO
Deep web接口查询能力估计
查询接口
查询能力
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Long-term results of a simultaneous trial of deep brain and motor cortex stimulation in refractory neuropathic pain
来源期刊 临床转化神经医学(英文版) 学科 医学
关键词
年,卷(期) 2017,(1) 所属期刊栏目
研究方向 页码范围 4-15
页数 12页 分类号 R741
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (1)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2006(1)
  • 参考文献(1)
  • 二级参考文献(0)
2017(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
引文网络交叉学科
相关学者/机构
期刊影响力
神经科学(英文)
季刊
2096-5958
10-1534/R
Xueyuan Building Tsi
出版文献量(篇)
176
总下载数(次)
0
总被引数(次)
0
论文1v1指导