Hydrothermal Synthesis and Characterization of Copper Glycinate (Bio-MOF-29) and Its <i>in Vitro</i>Drugs Adsorption Studies

• 作者: Muhammad Athar Tabinda Sattar
• 来源期刊: 无机化学期刊(英文)
• 学科: 化学
• 关键词: Bio-Metal Organic Framework Glycine Single Crystal XRD Analysis High Performance Liquid Chromatography Terazosine HCl TELMISARTAN Glimpiride Rosuvastatin Bio-MOF-29
• 年，卷（期）: 2017,（2）
• 页码范围: 17-27
• 页数: 11页
• 分类号: O6

摘要

A new porous compound, Copper glycinate (Bio-MOF-29), [Cu(C2H4NO2)2 (H2O)] has been synthesized by the hydrothermal method and characterized by single crystal XRD analysis. Bio-MOF-29 crystallized in orthorhombic crystal system with P212121 space group. In vitro adsorption studies of four different drugs, terazosine hydrochloride, telmisartan, glimpiride and rosuvastatin have been carried out for Bio-MOF-29. Drugs adsorption estimations of drugs loaded Bio-MOF-29 have been carried out through High Performance Liquid Chromatography (HPLC), which reveals that these drugs are successfuly adsorbed in it. Also the slow release of adsorbed drugs after intervals was observed through HPLC. Thermograms and powder XRD patterns of Bio-MOF-29 before and after drugs adsorption were also recorded to elaborate the phenomenon of drugs adsorption in Bio-MOF-29.