N-Myc Inhibition: Advances in Neuroblastoma Treatment

• 作者: Md Kamrul Hasan
• 来源期刊: 细胞生物学(英文)
• 学科: 医学
• 关键词: NEUROBLASTOMA N-MYC PI3K/mTOR PARP1 PD-L1 HAUSP
• 年，卷（期）: 2017,（3）
• 页码范围: 27-34
• 页数: 8页
• 分类号: R73

摘要

Neuroblastoma (NBL) is one of the most common solid tumors and around 15% of cancer mortality in children. Amplification of the N-Myc proto-oncogene is strongly correlated with advanced disease and poor clinical outcome in NBL. Recent studies described that ubiquitin-specific protease 7 (USP7;also known as HAUSP) interacts with N-Myc, induces deubiquitination and subsequent stabilization of N-Myc that in-turn potentiates N-Myc function, and treatment with the HAUSP inhibitor (P22077) blocked such effects.