Recombinant Human REG I<i>α</i>Aggregates <i>Staphylococcus aureus</i>—Exhibits a Lectin-Like Function

• 作者: Kazuaki Ohashi Koji Nata Nausheen Jamal Takamasa Nonaka Yuichiro Kezuka
• 来源期刊: 生命科学与技术进展(英文)
• 学科: 医学
• 关键词: REG Proteins Lectin-Like Activity Bacterial Aggregation
• 年，卷（期）: 2017,（3）
• 页码范围: 79-90
• 页数: 12页
• 分类号: R73

摘要

Staphylococcus aureus is pathogenic to humans with worldwide health care concern due to its ability to evade the immune system and develop resistance to multiple drugs. Reg family proteins are C-type lectins with antimicrobial properties. Bacterial aggregation through binding to microbial cell surface sugar and/or lipid moieties is key mechanism employed in the process. In the present study we have analysed the antimicrobial effect of human REG Iα on S. aureus. Aggregation of mid-log phase culture of S. aureus was observed in presence of purified recombinant REG Iα. Therefore REG Iα can be applied in eliminating S. aureus infections in humans.