Synthesis, Characterization and Analysis of Leishmanicide Ability of the Compound [Ru(Cl)<sub>3</sub>(H<sub>2</sub>O)<sub>2</sub>(gly)]

• 作者: A. T. B. N. Ribeiro Adriano Buzutti de Siqueira Anderson Dourado Galvã Claudia Cristina de Sousa Pereira Fabricio Tarso de Moraes I. C. C. de Assis Salama Katia Meirelles Duarte de Sousa Marcio Adriano S. Chagas o Wagner Batista dos Santos Wagner Welber Arrais-Silva
• 来源期刊: 无机化学期刊(英文)
• 学科: 化学
• 关键词: RUTHENIUM GLYCINE Spectroscopy Infrared TG/DTG and TG/DTA AMINO Acid
• 年，卷（期）: 2017,（4）
• 页码范围: 89-101
• 页数: 13页
• 分类号: O6

摘要

Studies of coordinated compounds containing ruthenium (Ru2+ and Ru3+) have shown very effective in vitro results for the treatment of cancer and neglected diseases such as leishmaniasis. In this paper, we present the synthesis of the compound [Ru(Cl)3(H2O)2(gly)], which was characterized by spectroscopic (Ultraviolet-visibleand infrared) and thermal analysis (Thermogravimetry/Derived Thermogravimetry and Thermogravimetry/Differential Thermal Analysis). The analysis of the compound in the Ultraviolet-visibleregion showed a 290 nm band λmax (ε= 1.685 × 103 L·cm-1·mol-1), attributed to the ligand metal charge transfer (LMCT). The spectroscopy (IR) showed major vibrational bands at δa (-COO-) 1664 cm-1, δs (-COO-) 1388 cm-1, δs () 1571 cm-1 and δs (CCN) 889 cm-1. The thermal analysis by TG/DTG and TG-DTA indicated that the complex has five consecutive stages of decomposition: at 115°C (TG = 12.18%;Calculated = 11.32%) H2O (coordinating water), exothermic peaks at 230°C, 307°C, 440°C and 463°C due to oxidative decomposition of glycine, followed by the formation of RuClO residue at 665°C (TG = 41.11%;Calculated = 40.81%). The thermal characterization suggested the stoichiometry of the complex [RuCl3(H2O)2(gly)]. The antileishmanial capacity of this compound was also evaluated and the results indicated a 31% decrease in the parasitic infection of macrophages and a 1.5 to 3 fold reduction in the number of parasites per cell after treatment with 100 μg/mL of the complex. These results support the possible use of this compound as a therapeutic alternative against medical and veterinary parasites.