Motivated by PID control simplicity, robustness and validity to deal with the nonlinearity and uncertainties of dynamics, through simulating the intelligent behavior of human manual control, and only using the elementary information on hand, this paper introduces a simple formulation to represent prior knowledge and experiences of human manual control, and proposes a simple and practicable control law, named Human-Simulating Intelligent PID control (HSI-PID), and the simple tuning rules with the explicit physical meaning. HSI-PID control can not only easily incorporate prior knowledge and experiences of experts control into the controller but also automatically acquire knowledge of control experiences from the past control behavior to correct the control action online. The theoretical analysis and simulation results show that: HSI-PID control has the better flexibility, stronger robustness, and especially the faster self-learning ability, and it can make the motion of system identically track the desired response, whether the controlled system has the strong nonlinearity and uncertainties of dynamics or not, even under the actions of uncertain, varying-time and strong disturbances.