Radio Pet Therapy of Healthy Wistar Rats with <sup>64</sup>CuCl<sub>2</sub>Labeled to <sup>64</sup>Cu(AcAc)<sub>2</sub>Supported in Functionalized TiO<sub>2</sub>Nanoparticles

• 作者: Francisco Rodríguez Reinoso Juan C. Manrique-Arias Pamela Larraza Paola Ramírez Tessy López
• 来源期刊: 封装与吸附期刊(英文)
• 学科: 化学
• 关键词: PET Therapy NANOPARTICLES FUNCTIONALIZED Titania (F-Tio2) Titanium Acetylacetonate [Cu (AcAc)2] Cu(Acac)2/F-Tio2 PET Lesion Detection Imaging
• 年，卷（期）: 2017,（3）
• 页码范围: 121-126
• 页数: 6页
• 分类号: O6

摘要

In recent years Copper-64 in the chemical form of copper chloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy. The aim of this research was to determine the biodistribution and the labeling of radio nanoparticle with 64CuCl2, the nanoparticles Cu(acac)2/F-TiO2 were mixed with 64CuCl2 (20-37 MBq), then the final solution was used to injected healthy Wistar rats to probe the absorption of nanoparticle inside tissue trough of the groups OH that are formed during the functionalization of the Cu(acac)2/F-TiO2. The “in vivo” evaluation after realize the images study in micro PET equipment, uptake of the radio-nanoparticle was observed in the digestive system in the healthy Wistar rats.