Itopride for gastric volume,gastric emptying and drinking capacity in functional dyspepsia

• 作者: Aamir Abbas Maseeh Uz Zaman Rakhshanda Bilal Safia Awan Shahab Abid Wasim Jafri
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: ITOPRIDE 胃的倒空 胃的住所 功能的消化不良 消化不良
• 年，卷（期）: 2017,（1）
• 页码范围: 74-80
• 页数: 7页
• 分类号: R57

摘要

AIM To study the effect of itopride on gastric accommodation, gastric emptying and drinking capacity in functional dyspepsia（FD）. METHODS Randomized controlled trial was conducted to check the effect of itopride on gastric accommodation, gastric emptying, capacity of tolerating nutrient liquid and symptoms of FD. We recruited a total of 31 patients having FD on the basis of ROME III criteria. After randomization, itopride was received by 15 patients while 16 patients received placebo. Gastric accommodation was determined using Gastric Scintigraphy. 13 C labeled octanoic breadth test was performed to assess gastric emptying. Capacity of tolerating nutrient liquid drink was checked using satiety drinking capacity test. Theintervention group comprised of 150 mg itopride. Patients in both arms were followed for 4 wk. RESULTS Mean age of the recruited participant 33 years（SD = 7.6） and most of the recruited individuals, i.e., 21（67.7%） were males. We found that there was no effect of itopride on gastric accommodation as measured at different in volumes in the itopride and control group with the empty stomach（P = 0.14）, at 20 min（P = 0.38）, 30 min（P = 0.30）, 40 min（P = 0.43）, 50 min（P = 0.50）, 60 min（P = 0.81）, 90 min（P = 0.25） and 120 min（P = 0.67）. Gastric emptying done on a sub sample（n = 11） showed no significant difference（P = 0.58） between itopride and placebo group. There was no significant improvement in the capacity to tolerate liquid in the itopride group as compared to placebo（P = 0.51）. Similarly there was no significant improvement of symptoms as assessed through a composite symptom score（P = 0.74）. The change in QT interval in itopride group was not significantly different from placebo（0.10）. CONCLUSION Our study found no effect of itopride on gastric accommodation, gastric emptying and maximum tolerated volume in patients with FD.