Equally Knocking on the Door of Medical Breakthroughs: Safety and Efficacy of a New Anti-Cancer Drug Pamica (PICNH<sub>2</sub>Ca) for Late Stage Cancer Patients

• 作者: Fang Liu Haixiang Lin
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: CANCER IMMUNOTHERAPY DS RNA TLR3 Terminal CANCER ADJUVANT PICKCa PIKA Pamica
• 年，卷（期）: swkxyyxyw,（2）
• 页码范围: 49-54
• 页数: 6页
• 分类号: R73

摘要

The composition of Pamica (PICNH2Ca2) is dsRNA polyI:C, non-biotics amino compounds and CaCl2. It is the second generation noncytotoxic product of PICKCa (PIKA) adjuvant which was found effective in phase II clinical trial for PICKCa rabies vaccine and phase I trial for PICKCa hepatitis B vaccine in Singapore. With their knowledge and consent, cancer patients, regardless of their tumor types or performance status (ECOG above 5 or ECOG > 20), who were unresponsive to standard treatment, were treated free of charge with Pamica by injection or nasal spray. The primary results indicated that Pamica had no side effect except for a few cases of local pain in the site of injection and appeared to markedly improve cancer patients’ appetite, physical strength, quality of life and extended patients’ life for months and counting. These preliminary findings underlined promise of this potentially life-saving drug. In the hope of cooperating with the proper authorities, companies, and hospitals to benefit patients at the earliest opportunity, we share our findings in this paper.