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摘要:
An assessment of the efficacy targets of drugs that represent an opportunity for targeted therapy is fundamental to the development of post-genomic research strategies within the pharmaceutical industry. Identification and validation of efficacy target is an important process in drug discovery and development. Extensive drug discovery efforts have yielded many approved and candidate drugs. Although sever drug databases provide the drug and their corresponding targets, there is an insufficient coverage of the clinical trial drugs over the past decades. Here, we conduct a comprehensive survey for current clinical trial drugs, therapeutic targets. The analysis contents include: 1) collect clinical trial drugs from different sources, 2) By analysis of the literature, we summarize the criteria for assign therapeutic targets for each drug based on its indication. The knowledge of these drugs and their targets is useful not only for drug discovery and development of targeted therapy, but also for facilitating the discovery of systems pharmacology.
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篇名 Construction of Enriched Resource for Primary Therapeutic Targets of Approved and Clinical Trial Drugs
来源期刊 生物科学与医学(英文) 学科 医学
关键词 DRUG DRUG TARGET INDICATION Protein TARGET of a DRUG TARGET of Disease
年,卷(期) 2017,(3) 所属期刊栏目
研究方向 页码范围 1-6
页数 6页 分类号 R73
字数 语种
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节点文献
DRUG
DRUG
TARGET
INDICATION
Protein
TARGET
of
a
DRUG
TARGET
of
Disease
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
生物科学与医学(英文)
月刊
2327-5081
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
721
总下载数(次)
0
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