GnRH Antagonist Protocol: Is It Optimal for All Patients of Different Ages Undergoing <i>In Vitro</i>Fertilization and Embryo Transfer?

• 作者: Haiyan Lin Qingxue Zhang Weijie Xing
• 来源期刊: 性医学进展(英文)
• 学科: 医学
• 关键词: GNRH AGONIST GNRH ANTAGONIST IVF-ET
• 年，卷（期）: 2017,（4）
• 页码范围: 153-160
• 页数: 8页
• 分类号: R73

摘要

Background: To assess the effect of these two protocols in patients of different ages. Methods: 1923 in vitro fertilization and embryo transfer (IVF-ET) cycles were divided into two groups: a GnRH-ant protocol group and GnRH-a long protocol group, and then every group were subdivided into four age ranges. The general materials and IVF outcomes were compared. Results: The incidence of OHSS fluctuated from 0% to 2.37% with GnRH-ant protocol, which was significantly lower than another (P P Conclusion: The antagonist protocol should be considered in patients with a high ovarian response (e.g., PCOS patients) to avoid OHSS. Older patients (>35 years) could be treated with the antagonist protocol.