Synthesis of 1,3-Oxazepine Derivatives Derived from 2-(1H-Benzo[d][1,2,3]Triazol-1-yl) Acetohydrazide by Using Microwave Irradiation

• 作者: Nihad Ismail Taha
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Hydrazone MICROWAVE Oxezapine BENZOTRIAZOLE HYDRAZINE
• 年，卷（期）: 2017,（3）
• 页码范围: 219-228
• 页数: 10页
• 分类号: O6

摘要

A series of Schiff base and their derivative (oxazepine) have been synthesized. 8-hydrazone(schiff-bases) derivatives type (E)-2-(1H-benzo[d][1,2,3]triazole-1-yl)-N-(substituted benzylidene)aceto-hydrazide were prepared by condensation 1H-benzo[d][1,2,3]triazol-1-yl)hydrazine with various aromatic aldehyde in ethanol in the presence of dimethyl formamid or acetic acid as catalyst by using MWI to yield the Schiff bases. These Schiff’s base on treatment with Maleic anhydride in dry conditions by using MWI to give 7-membered heterocyclic ring system (oxezapine) of (2-(1H)benzo[d][1,2,3]triazol-1-yl)-N-(2-(substituted penyl)-4, 7-dioxo-4,7-dihydro-1,3-oxazepin-3-(2H)-yl)acetamide. The purity of the compounds was confirmed by TLC. The final products were identified by their melting point, IR, 1HNMR, and UV-visible spectra.