Risk factors for mortality in postoperative peritonitis in critically ill patients

• 作者: Audrey Tawa Benjamin Duteurtre Nicolas Nesseler Philippe Seguin Raphaelle Larmet Yannick Mallédant Yoann Launey
• 来源期刊: 世界重症医学杂志
• 学科: 医学
• 关键词: MORTALITY POSTOPERATIVE PERITONITIS Risk FACTORS SURGERY
• 年，卷（期）: 2017,（1）
• 页码范围: 48-55
• 页数: 8页
• 分类号: R

摘要

AIM To identify the risk factors for mortality in intensive care patients with postoperative peritonitis(POP).METHODS This was a retrospective analysis using a prospective database that includes all patients hospitalized in a surgical intensive care unit for POP from September 2006 to August 2011.The data collected included demographics,comorbidities,postoperative severity parameters,bacteriological findings,adequacy of antimicrobial therapy and surgical treatments.Adequate source control was defined based on a midline laparotomy,infection source control and intraoperative peritoneal lavage.The number of reoperations needed was also recorded.RESULTS A total of 201 patients were included.The overall mortality rate was 31%.Three independent risk factors for mortality were identified:The Simplified Acute PhysiologicalⅡScore(OR=1.03;95%CI:1.02-1.05,P<0.001),postoperative medical complications(OR=6.02;95%CI:1.95-18.55,P<0.001)and the number of reoperations(OR=2.45;95%CI:1.16-5.17,P=0.015).Surgery was considered as optimal in 69%of the cases,but without any significant effect on mortality.CONCLUSION The results from the large cohort in this study emphasize the role of the initial postoperative severity parameters in the prognosis of POP.No predefined criteria for optimal surgery were significantly associated with increased mortality,although the number of reoperations appeared as an independent risk factor of mortality.