Toxicity and Viral Load in Urine during Valganciclovir Therapy in Premature Infants

• 作者: Henrica L. M. Van Straaten Marieke A. C. Hemels Merel Boesveld
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: CMV PREMATURE INFANTS VALGANCICLOVIR Treatment
• 年，卷（期）: 2017,（8）
• 页码范围: 275-282
• 页数: 8页
• 分类号: R73

摘要

Cytomegalovirus (CMV) infection is the most important cause of mental retardation and sensorineural hearing loss. Antiviral treatment with valganciclovir, a relatively new but potential toxic oral drug, is recommended to prevent further hearing deterioration. In this retrospective cohort study we evaluated the relation between the dose of valganciclovir and the reduction of CMV viral load, as well as the toxicity. All neonates with gestational age